SciELO - Scientific Electronic Library Online

 
vol.108 número9-10Global challenges in the risk assessment of nanomaterials: relevance to South AfricaDarwin as a geologist in Africa - dispelling the myths and unravelling a confused knot índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • En proceso de indezaciónSimilares en Google

Compartir


South African Journal of Science

versión On-line ISSN 1996-7489
versión impresa ISSN 0038-2353

Resumen

FEATHERSTON, Jonathan  y  DURAND, Pierre M.. Cooperation and conflict in cancer: an evolutionary perspective. S. Afr. j. sci. [online]. 2012, vol.108, n.9-10, pp.1-5. ISSN 1996-7489.

Evolutionary approaches to carcinogenesis have gained prominence in the literature and enhanced our understanding of cancer. However, an appreciation of neoplasia in the context of evolutionary transitions, particularly the transition from independent genes to a fully integrated genome, is largely absent. In the gene-genome evolutionary transition, mobile genetic elements (MGEs) can be studied as the extant exemplars of selfish autonomous lower-level units that cooperated to form a higher-level, functionally integrated genome. Here, we discuss levels of selection in cancer cells. In particular, we examine the tension between gene and genome units of selection by examining the expression profiles of MGE domains in an array of human cancers. Overall, across diverse cancers, there is an aberrant expression of several families of mobile elements, including the most common MGE in the human genome, retrotransposon LINE 1. These results indicate an alternative life-history strategy for MGEs in the cancers studied. Whether the aberrant expression is the cause or effect of tumourigenesis is unknown, although some evidence suggests that dysregulation of MGEs can play a role in cancer origin and progression. These data are interpreted in combination with phylostratigraphic reports correlating the origin of cancer genes with multicellularity and other potential increases in complexity in cancer cell populations. Cooperation and conflict between individuals at the gene, genome and cell level provide an evolutionary medicine perspective of cancer that enhances our understanding of disease pathogenesis and treatment.

        · texto en Inglés     · Inglés ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons