SciELO - Scientific Electronic Library Online

 
vol.104 número1-2Prevalence of Escherichia coli O157 strains in cattle, pigs and humans in North West province, South Africa índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Artigo

Indicadores

Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Em processo de indexaçãoSimilares em Google

Compartilhar


South African Journal of Science

versão On-line ISSN 1996-7489
versão impressa ISSN 0038-2353

Resumo

BISHOP, A. Ozlem Tastan; BEER, Tjaart A. P. de  e  JOUBERT, Fourie. Protein homology modelling and its use in South Africa. S. Afr. j. sci. [online]. 2008, vol.104, n.1-2, pp.2-6. ISSN 1996-7489.

Homology modelling is an important computational technique, within structural biology, to determine the 3D structure of proteins. It uses available high-resolution protein structures to produce a model of a protein of similar, but unknown, structure. We describe the essential steps in the process, and discuss the circumstances in which homology modelling is likely to lead to a useful result. Homology modelling plays a valuable role in drug design, and we illustrate this by one example, anti-SARS inhibitors. In South Africa, homology modelling has been applied to proteins that may be relevant for drug design in connection with diseases as well as in other potential industrial applications. The use to date has been limited, however, so this article aims to introduce this useful and cost-effective technique to a wider community.

        · texto em Inglês     · Inglês ( pdf )

 

Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons