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South African Dental Journal

On-line version ISSN 0375-1562
Print version ISSN 0011-8516


GEORGE, C et al. Association between dental and periodontal conditions with chronic kidney disease: A cross-sectional analysis of urban South Africans. S. Afr. dent. j. [online]. 2022, vol.77, n.1, pp.3-11. ISSN 0375-1562.

INTRODUCTION: Oral diseases are preventable causes of poor health outcomes in people with chronic kidney disease (CKD). AIMS AND OBJECTIVES: Investigate the association between dental and periodontal conditions with kidney function and determine whether inflammation mediate the association between periodontitis and CKD. DESIGN: Cross-sectional analysis of 1551 South African adults of mixed ancestry. METHODS: CKD was classified as estimated glomerular filtration rate (eGFR) <60mL/min/1.73m2. Oral profile was captured by decayed, missing, filled teeth index (DMFTi), bleeding on probing (BOP), pocket depth (PD), clinical attachment loss (CAL), and periodontitis classified as PD >4 mm. RESULTS: Overall, 6% had CKD, with 93% and 66% of participants with and without CKD, respectively having a high DMFTi (p<0.0001). Further, 84% (CKD) and 43% (without CKD) were edentulous (p<0.0001). A great proportion of the dentate sub-sample (n=846) had periodontitis, however, BOP, PD >4mm and CAL >4mm were similar between the groups. DMFTi was associated with eGFR and prevalent CKD (p<0.023), with this association driven by the Missing component. Periodontitis was not associated with eGFR nor CKD (p>0.282 CONCLUSION: In routine care of people with CKD, attention should be given to oral health.

Keywords : chronic kidney disease; oral disease; periodontitis; dental; tooth loss; Africa.

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