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South African Dental Journal

On-line version ISSN 0375-1562
Print version ISSN 0011-8516


PECK, MT; HISS, D; STEPHEN, L  and  MABOZA, E. Antibiotic release from leukocyte-and platelet-rich fibrin (L-PRF) -an observational study. S. Afr. dent. j. [online]. 2018, vol.73, n.4, pp.268-270. ISSN 0375-1562.

INTRODUCTION: Leukocyte- and platelet-rich fibrin (L-PRF), an autologous derived platelet and leukocyte concentrate, was first introduced by Choukroun et al. in 2001 and is currently used in a wide range of medical procedures. Although various biological properties have been attributed to L-PRF, nevertheless, when tested for inherent antimicrobial activity, the biomaterial fails to demonstrate a clear and significant effect against a range of oral microbiota. Aims and objectives: To determine whether L-PRF prepared after a single oral dose of antibiotic had any significant antimicrobial effect over a 48 hour period. METHODS: An in vitro laboratory study for which L-PRF was prepared from a single healthy volunteer who had previously ingested oral antibiotics. The resultant prepared L-PRF was tested for antimicrobial activity against Streptococcus mutans (ATCC 35668) using standard laboratory methods RESULTS: For all samples tested, measurable zones of inhibition were clearly visible after 24 hours, but were absent after 48 hours CONCLUSIONS: L-PRF prepared after a single dose of oral antibiotic results in a measurable antimicrobial effect that is sustainable for 24 hours. Although L-PRF will remain structurally intact for a few days, it does not appear to influence the duration of the antimicrobial activity

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