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South African Dental Journal

On-line version ISSN 0375-1562
Print version ISSN 0011-8516


MINIGGIO, HD  and  RAUBENHEIMER, EJ. Immune-mediated response of bone in osteomyelitis - fundamental concepts. S. Afr. dent. j. [online]. 2016, vol.71, n.10, pp.493-495. ISSN 0375-1562.

Advancement of knowledge on the role of the immune system in bone metabolism has uncovered a dynamic interdisciplinary research field labelled "osteoimmunology". The immune system provides stem cells for bone remodelling and elaborates cytokines under both physiological- and pathological circumstances which map the local response of bone cells and alter the phenotypic expression of bone. This manuscript provides an overview of the interaction between the immune system and bone in the different stages of osteomyelitis and correlates the inductive patterns with the radiologic appearances.

Keywords : osteoimmunology; immune regulatory mediators; bone remodelling; osteomyelitis.

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