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South African Dental Journal

On-line version ISSN 0375-1562
Print version ISSN 0011-8516


PECK, MT; HISS, D  and  STEPHEN, L. Factors affecting the preparation, constituents, and clinical efficacy of leukocyte- and platelet- rich fibrin (L-PRF). S. Afr. dent. j. [online]. 2016, vol.71, n.7, pp.298-302. ISSN 0375-1562.

Platelet-rich fibrin (PRF) was first introduced by Choukroun et al, in 2001 as a method of concentrating autologous human leukocytes, platelets and fibrin for autotransplantation into surgical wound sites to accelerate healing. Even though several clinical reports have documented the use of L-PRF, controversy still exists with regards to many aspects of this biomaterial. Diverse publications report the use of non-standardised methods to prepare L-PRF, resulting in variable clinical results. The impact of the type of centrifuge, as well as of the growth factor release kinetics, have recently been studied and have yielded new insights into the structure and function of L-PRF. The presence of bone morphogenetic proteins as well as stem cells has also been documented. In this report we analyse various factors affecting L-PRF preparation and its constituents and highlight some of the controversies surrounding the biomaterial.

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