Abstract

PULIKOTTIL, SJ  and  NATH, S. Potential of clove of Syzygium aromaticum in development of a therapeutic agent for periodontal disease: A review. S. Afr. dent. j. [online]. 2015, vol.70, n.3, pp.108-115. ISSN 0375-1562.

INTRODUCTION: Clove (Syzygium aromaticum) is a plant-derived spice that has been traditionally used as a natural medicine for the treatment for various ailments including dental diseases. AIM AND OBJECTIVE: To present a comprehensive report on the properties of clove based on an analysis of contemporary scientific and professional literature in order to explore the prospects for its application in the treatment of plaque-induced periodontal diseases. METHODS: An online search was performed in PubMed and Google Scholar using a combination of key words which included clove buds, clove essential oil, eugenol, Eugenia caryophyllata, spices, medicinal plant, chemical composition, biological effect, therapeutic use, anti-bacterial, anti-fungal, anti-viral, anti-oxidant, anti-inflammatory, anaesthetic, periodontal, dental, and periodontitis. RESULTS: In vitro studies have shown Syzygium aromati-cum to have bacteriostatic, bactericidal, anti-viral, anti-mycotic, anti-oxidant, anti-carcinogenic, anaesthetic and analgesic properties. Clove oil has a specific anti- inflammatory property as it inhibits the cyclo-oxygenase-2 and lipo-oxygenase enzymes. CONCLUSION: Clove and its derivatives have a definite potential to be used as specific anti-plaque and anti-inflammatory agents for the treatment of periodontal disease. Future research should concentrate on designing new formulations based on clove derivatives in the form of local drug delivery system or topical agents for the treatment of periodontal diseases.

Keywords : Syzygium aromaticum; periodontitis; biofilm; non-surgical periodontal therapy.

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