RESEARCH ARTICLE

 

Spectral and thermal characterization and antimicrobial effect of 3-(5-H/Me/Cl/NO₂-1H-benzimidazol-2-yl)-benzene-1,2-diols and some transition metal complexes

 

 

Aydin Tavman^{I, *}; A. Seher Birteksoz^II; Faruk Oksuzomer^III

^IIstanbul University, Faculty of Engineering, Department of Chemistry, 34320, Avcilar, Istanbul, Turkey
^IIIstanbul University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, 34452, Beyazit, Istanbul, Turkey
^IIIIstanbul University, Faculty of Engineering, Department of Chemical Engineering, 34320, Avc lar, Istanbul, Turkey

 

 

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ABSTRACT

3-(5-H/Me/Cl/NO₂-1H-benzimidazol-2-yl)-benzene-1,2-diols (HL_X; X = 1-4) ligands and HL₃ complexes with Fe(NO₃)₃, Cu(NO₃)₂, Co(NO₃)₂, Zn(NO₃)₂ have been synthesized and characterized. The structural representations of the compounds are proposed on the basis of elemental analysis, molar conductivity, TGA, mass, FT-IR, ¹H- and ¹³C-NMR spectrometry. All of the complexes are 1:1 electrolyte and have 1:1 M:L ratio except that of Cu(II).All of the complexes present fluorescence, the Co(II) complex showing the highest fluorescence intensity and the highest emission wavelength in comparison to the other complexes. Antibacterial activities of the ligands and the complexes formed by the HL₃ ligand were evaluated using the disk diffusion method against six bacteria and Candida albicans. HL₁, HL₂, HL₃ and [Cu(HL₃)(L₃)(H₂O)₂](NO₃)-H₂O show considerable antimicrobial activity toward S. epidermidis and C. albicans.

Keywords: Benzimidazole, benzene-1,2-diol, metal complexes, antimicrobial activity, fluorescence spectroscopy

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Acknowledgements

This work was supported by the Istanbul University Research Fund and TUBITAK (The Scientific and Technological Research Council of Turkey). COST project number: TBAG-U/185 (106T086).

 

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Submitted 20 April 2011
Revised 28 May 2012
Accepted 4 June 2012

 

 

* To whom correspondence should be addressed. E-mail: atavman@istanbul.edu.tr