RESEARCH ARTICLE

 

GC-MS analysis and antimicrobial activities of the non-polar extracts of Mundulea sericea

 

 

O. Mazimba^{I, *}; I.B. Masesane^I; R.R.T. Majinda^I; A. Muzila^II

^IDepartment of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana
^IIDepartment of Biological Sciences, University of Botswana, Private Bag 0022, Gaborone, Botswana

 

 

---

ABSTRACT

The composition of the non-polar extracts of the leaves, stem bark and twigs of Mundulea sericea (Fabaceae) were analyzed using GC-MS. Eight, five and eleven components were identified from the leaves, twigs and stem bark extract, respectively. The major components were identified as: caryophyllene (43.6 %) and cadina-3,9-diene (29.7 %) in the leaf extract, amorphene (34.4 %) and valencene (17.9 %) in the stem bark extract and isoledene (29.0 %) and α-gurjunene (22.4 %) from the twig extract. Sesquiterpenes were the major abundant components in the non-polar extracts. The leaf, stem bark and twig extracts showed weak antibacterial and antifungal activities.

Keywords: Mundulea sericea, GC-MS, non-polar, sesquiterpenes, antimicrobial

---

 

 

Full text available only in PDF format.

 

Acknowledgements

O.M. is grateful to the University of Botswana (Chemistry Department) for the fellowship. The assistance of Mr I. Morobe of the Department of Biological Sciences, University of Botswana during antibacterial testing are gratefully acknowledged.

 

References

1 D.J. Du Puy, J.-N. Labat, R. Rabevohitra, J.-F. Villiers, J. Bosser and J. Moat, The Leguminosae of Madagascar, Royal Botanic Gardens, Kew, UK, 2002.         [ Links ]

2 P. Kalavathi, P.A. Lakshmi and T. Pullaiah J. Ecotoxicol. Environ. Monit, 2006, 16, 239-242.         [ Links ]

3 L. Luyengi, I.S. Lee, W. Mar, H.H.S. Fong, J.M.Pezzuto and A.D. Kinghorn, Phytochemistry 1994, 36, 1523-1526.         [ Links ]

4 E.V. Rao, P. Sridhar and Y.R. Prasad, Phytochemistry 1997, 46, 1271-1274.         [ Links ]

5 O. Mazimba, I.B. Masesane and R.R.T Majinda, Nat. Prod. Res., 2011, 5, doi:10.1080/14786419.2011.616504.         [ Links ]

6 S. Cao, J.K. Schilling, J.S. Miller, R. Andriantsiferana, V.E. Rasamison, and D.G.I. Kingston, J. Nat. Prod., 2004, 67, 454-456.         [ Links ]

7 S. Ratsimamanga-Urverg, P. Rasoa naivo, C. Rabemanantsoa, A.R. Ratsimamanga and F. Frappier, Fitoterapia 1994, 65, 551-556.         [ Links ]

8 F. Guido, L.C. Pier, M. Ivano and B. Ammar, Food Chem, 2007, 100, 732-735.         [ Links ]

9 J. Li, J. Liu, H. Lan, M. Zheng and T. Rong, Front. Agri. China, 2009, 3, 40-42.         [ Links ]

10 O. Mazimba, R.R.T Majinda, C. Modibedi, I.B. Masesane, A. Cencic, and W. Chingwaru, Bioorg. Med. Chem., 2011, doi: 10.1016/j.bmc.2011. 07.006.         [ Links ]

11 G. Flamini, A. Bader, P.L. Cioni, A. Katbeh-Bader and I. Morelli, J. Agric. Food Chem., 2004, 52, 572.         [ Links ]

12 J. Safaei-Ghomi, H.A. Ebrahimabadi, Z. Djafari-Bidgoli and H. Batooli, Food Chem., 2009, 115, 1524-1528.         [ Links ]

13 P. Deomar, G. Costa-Elenilson, A. Filho, L.M.A. Silva, S.C. Santos, X.S. Passos, M.R. do Rosário and S.C. José, J. Braz. Chem. Soc., 2010, 21, 851-858.         [ Links ]

14 Radulovic N., Dordevic N., Markovic M. and Palic R., Bull. Chem. Soc. Ethiopia, 2010, 24, 67-76.         [ Links ]

15 A. Feizbakhsh and A. Naeemy, Bull. Chem. Soc. Ethiopia, 2011, 25, 461-464.         [ Links ]

16 K.M. Chang and G.H. Kim, J. Food Sci. Nutr, 2009, 14, 168-171.         [ Links ]

17 S.Comai, S. Dall'Acqua, A. Grillo, I. Castagliuolo, K. Gurung and G. Innocenti, Fitoterapia 2010, 81, 11.         [ Links ]

18 G. Pintore, M. Usai, P. Bradesi, C. Juliano, G. Boatto and F. Tomi, Flavour Fragr. J., 2002, 17, 15.         [ Links ]

19 G. Singh, O.P. Singh and S. Maurya, Program Cryst Growth Characterization, 2002, 45, 75-81.         [ Links ]

 

 

Received 18 August 2011
Revised 14 September 2011
Accepted 14 February 2012

 

 

* To whom correspondence should be addressed. E-mail: mazimbaof@yahoo.com