RESEARCH ARTICLE

 

The evaluation of novel camphor-derived ligands as catalysts in the asymmetric Henry reaction

 

 

Grant A. Boyle^I; Thavendran Govender^II; Hendrik G. Kruger^I; Glenn E.M. Maguire^I

^ISchool of Chemistry, University of KwaZulu-Natal, Durban 4000, South Africa
^IISchool of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban 4000, South Africa

 

 

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ABSTRACT

The evaluation of a series of camphor-derived ligands as catalysts in the asymmetric Henry reaction is reported. The synthesis of two novel derivatives is detailed and these molecules are also screened as catalysts in this reaction. The single crystal X-ray structure of one of the novel compounds is reported. The reaction is catalyzed with moderate to excellent yields and moderate enantioselectivity.

Keywords: Camphor, asymmetric catalysis, Henry reaction, chiral ligands

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Acknowledgements

This work was supported by grants from the National Research Foundation, GUN 2046819 (South Africa), Aspen Pharmacare and the University of KwaZulu-Natal.

 

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Received 27 February 2009
Revised 21 April 2009
Accepted 13 May 2009

 

 

*To whom correspondence should be addressed. E-mail: kruger@ukzn.ac.za