RESEARCH ARTICLE

 

KHSO₄-catalyzed three-component synthesis of α-aminonitriles

 

 

Hossein A. Oskooie; Majid M. Heravi; Mojgan Ebrahimzadeh; Bita Baghernejad

Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran

 

 

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ABSTRACT

A simple, convenient and general method has been developed for the synthesis of α-aminonitriles by a one-pot three-component condensation of aldehydes, amines and trimethyl silyl cyanide under solvent-free conditions in the presence of a catalytic amount of KHSO₄ in good yields. The new method compares well in terms of yields with alternative methods. In general the reaction times are much shorter and the work up much easier.

Keywords: One-pot, KHSO₄, trimethyl silyl cyanide, α-aminonitriles

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Acknowledgements

We are thankful to Azzahra University Research Council for partial financial support.

 

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Received 17 December 2008
Revised 25 February 2009
Accepted 18 March 2009

 

 

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