RESEARCH ARTICLE

Synthesis and antimicrobial activity of new α-aminophosphonic acid esters

Sanapalli S. Reddy; A.U. Ravi Sankar; C. Naga Raju^*; V. Koteswara Rao

Department of Chemistry, Sri Venkateswara University, Tirupati-517502, India

ABSTRACT

Synthesis of new a-aminophosphonic acid esters (3a-I) was accomplished by the reaction of equimolar quantities of phenyl ethyl glycine and various aryl aldehydes with diethyl/ dimethylphosphite in dry toluene at reflux temperature. All the structures of the newly synthesized a-aminophosphonic acid esters (3a-I) were established by elemental analysis, and IR, ¹H, ¹³C, ³¹P NMR and mass spectral data. The antimicrobial and antifungal activities of these compounds were evaluated and they exhibited significant activity.

Keywords: Phenyl glycine ethyl ester, aryl aldehydes, diethyl/dimethylphosphite, antimicrobial activity

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Acknowledgements

The authors express their thanks to Prof. C. Devendranath Reddy and Dr C. Suresh Reddy, Department of Chemistry, Sri Venkateswara University, Tirupati, India, for their encouragement and helpful discussion and the Directors, IISc, Bangalore, and CDRI, Lucknow, India, for the analytical and spectral data.

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Received 21 June 2008
Revised 1 August 2008
Accepted 1 October 2008

*To whom correspondence should be addressed. E-mail: naga_raju04@yahoo.co.in