RESEARCH ARTICLE

 

SnO₂/SiO₂ nanocomposite catalyzed one-pot, four-component synthesis of 2-amino-3-cyanopyridines

 

 

Ajeet A. Yelwande; Madhukar E. Navgire; Deepak T. Tayde; Balasaheb R. Arbad; Machhindra K. Lande^*

Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad (M.S.), 431004, India

 

 

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ABSTRACT

An efficient and rapid protocol for the synthesis of 2-amino-3-cyanopyridines by the cyclocondensation reaction of aromatic aldehydes, methyl ketones, malononitrile and ammonium acetate catalyzed by SnO₂/SiO₂ nanocomposite material at refluxed condition in ethanol was investigated. Nanocomposite (SnO₂/SiO₂) catalytic material has been synthesized by using the sol-gel method. The prepared catalytic materials were characterized by using X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FT-IR), Brunauer-Emmer-Teller (BET) surface area, and temperature-programmed desorption of ammonia (NH₃-TPD). Advantages of the present method include a simple work-up procedure, high yields of the products, low toxicity and easy recovery and reusability of the catalytic materials.

Keywords: : SnO₂/SiO₂, sol-gel, nanocomposite, 2-amino-3-cyanopyridines, heterogeneous catalyst

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Acknowledgements

The authors thank the Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India, for providing laboratory facilities, and the DST for providing financial help under the DST-FIST scheme.

 

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Received 6 December 2012
Revised 14 February 2012
Accepted 4 June 2012

 

 

* To whom correspondence should be addressed. E-mail: mkl_chem@yahoo.com