Resumo

OSKOOIE, Hossein A.; HERAVI, Majid M.; EBRAHIMZADEH, Mojgan  e  BAGHERNEJAD, Bita. KHSO₄-catalyzed three-component synthesis of α-aminonitriles. S.Afr.j.chem. (Online) [online]. 2009, vol.62, pp.102-104. ISSN 1996-840X.

A simple, convenient and general method has been developed for the synthesis of α-aminonitriles by a one-pot three-component condensation of aldehydes, amines and trimethyl silyl cyanide under solvent-free conditions in the presence of a catalytic amount of KHSO₄ in good yields. The new method compares well in terms of yields with alternative methods. In general the reaction times are much shorter and the work up much easier.

Palavras-chave : One-pot; KHSO₄; trimethyl silyl cyanide; α-aminonitriles.

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