SHORT COMMUNICATION

 

Characterization and cardiovascular effects of (13S)-9α,13α-epoxylabda-6β(19),15(14)diol dilactone, a diterpenoid isolated from Leonotis leonurus

 

 

Kene C. Obikeze^I; Jean M. McKenzie^{II, *}; Ivan R. Green^III; Pierre Mugabo^I

^IDepartment of Pharmacology, School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa
^IICentral Analytical Facility, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa
^IIIDepartment of Chemistry, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa

 

 

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ABSTRACT

A new diterpenoid, (13S)-9α,13α-epoxylabda-6β(19),15(14)diol dilactone (1), was isolated from Leonotis leonurus and the structure determined via NMR analysis. The compound causes significant changes in blood pressure of anaesthetized normotensive rats and exhibits a negative chronotropic effect.

Keywords: Leonotis leonurus, diterpenoid, NMR analysis, chronotropic effect

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Full text available only in pdf format.

 

Acknowledgement

Financial support was provided by the South African National Research Foundation.

 

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Received 11 August 2008
Revised 10 September 2008
Accepted 15 September 2008

 

 

* To whom correspondence should be addressed. E-mail: jean.mckenzie@gmail.com