Abstract

BOPAPE, Pheagane G.; WAGENAAR, Chrisna; POKA, Madan  and  BRONKHORST, Elmien. Vitamin D supplementation in a post-pandemic era: A narrative review. SAFP [online]. 2023, vol.65, n.1, pp.1-6. ISSN 2078-6204.  https://doi.org/10.4102/safp.v65i1.5752.

Vitamin D is a fat-soluble molecule referring to the different isoforms, ergocalciferol (D2) and cholecalciferol (D3). Its physiological functions include increasing calcium serum concentrations. 25-hydroxyvitamin D₃ (25(OH)D) (Calcifediol), a non-active, circulating instant precursor is seen as a pre-hormone. Studies have shown that a deficiency in calcifediol is related to chronic conditions such as cardiovascular, musculoskeletal, immune system, neurological, and anti-neoplastic functions. Vitamin D supplementation has shown its benefit as prophylaxis and treatment during the coronavirus disease 2019 (COVID-19) pandemic and an increase in the prescribing of vitamin D supplementation has been observed. The intention of this review article is to provide guidance on the recommended dosage regimen as a prophylactic measure during COVID-19 and its use as a supplement in general. From this review article, it is clear that vitamin D has an important role to play not only in COVID-19 but also in various other health aspects of the human body. CONTRIBUTION: This review article highlighted the role of vitamin D in managing vitamin D deficiency and its role as a supplement in the management of respiratory tract infections, especially COVID-19. This overview can assist physicians in optimising healthcare by optimised dosing recommendations and indications

Keywords : vitamin D; COVID-19; chronic diseases; deficiency; calcifediol; cholecalciferol.

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