Abstract

LI, Jian-Ping et al. Straightforward synthesis of a new series of α-(arylamino thiocarbonyloxy) hydrocarbylphosphonates. S.Afr.j.chem. (Online) [online]. 2008, vol.61, pp.05-08. ISSN 1996-840X.

A convenient, straightforward, two-step reaction of α-hydroxyhydrocarbylphosphonates with arylisothiocyanates in the presence of catalytic amounts of sodium methoxide in 1,2-dichloroethane as solvent produced various new α-(arylamino thiocarbonyloxy) hydrocarbylphosphonates in excellent yields. Their structures have been confirmed by their IR, ¹H NMR and ³¹P NMR spectra and by elemental analysis. The preliminary antisepsis activity and protein activity of some of the compounds were identified.

Keywords : Phosphonates; arylisothiocyanates; A-hydroxyhydrocarbylphosphonates; synthesis; activity.

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