Scielo RSS <![CDATA[SAMJ: South African Medical Journal]]> http://www.scielo.org.za/rss.php?pid=0256-957420200010&lang=en vol. 110 num. 10 lang. en <![CDATA[SciELO Logo]]> http://www.scielo.org.za/img/en/fbpelogp.gif http://www.scielo.org.za <![CDATA[<b>Modified full-face snorkel masks as personal protective equipment for COVID-19 in South Africa</b>]]> http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742020001000001&lng=en&nrm=iso&tlng=en <![CDATA[<b>Clinical v. laboratory-based screening for COVID-19 in asymptomatic patients requiring acute cardiac care</b>]]> http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742020001000002&lng=en&nrm=iso&tlng=en <![CDATA[<b>Metabolie alkalosis in hospitalised COVID-19 patients: A window to the pathogenesis?</b>]]> http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742020001000003&lng=en&nrm=iso&tlng=en <![CDATA[<b>Reflections for global public health research and evidence-based medicine during the COVID-19 pandemic</b>]]> http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742020001000004&lng=en&nrm=iso&tlng=en <![CDATA[<b>Research imperialism resurfaces in South Africa in the midst of the COVID-19 pandemic - this time, via a digital portal</b>]]> http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742020001000005&lng=en&nrm=iso&tlng=en <![CDATA[<b>Is the COVID-19 regulation that prohibits parental visits to their children who are patients in hospital invalid in terms of the Constitution? What should hospitals do?</b>]]> http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742020001000006&lng=en&nrm=iso&tlng=en This article deals with whether the COVID-19 regulation that prohibits parental visits to their children who are patients in hospital is invalid in terms of the Constitution of South Africa. The article contends that the ban on visits by parents to their children in hospital is a violation of the children's rights provisions of the Constitution regarding the 'best interests of the child', and the 'best interests standard' in the Children's Act 38 of 2005. The article also points out that the regulations are not saved by the limitations clause of the Constitution, because the restriction is not 'reasonable and justifiable' and a 'less restrictive means' can be used to achieve the same purpose of preventing the spread of the COVID-19 virus. The article concludes that the relevant regulation is legally invalid, and hospitals would be fully justified in allowing parental visits to child patients provided proper precautions are taken to contain the virus. <![CDATA[<b>Essential medicine selection during the COVID-19 pandemic: Enabling access in uncharted territory</b>]]> http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742020001000007&lng=en&nrm=iso&tlng=en The COVID-19 pandemic requires urgent decisions regarding treatment policy in the face of rapidly evolving evidence. In response, the South African Essential Medicines List Committee established a subcommittee to systematically review and appraise emerging evidence, within very short timelines, in order to inform the National Department of Health COVID-19 treatment guidelines. To date, the subcommittee has reviewed 14 potential treatments, and made recommendations based on local context, feasibility, resource requirements and equity. Here we describe the rapid review and evidence-to-decision process, using remdesivir and dexamethasone as examples. Our experience is that conducting rapid reviews is a practical and efficient way to address medicine policy questions under pandemic conditions. <![CDATA[<b>Opportunistic pathogenic fungal co-infections are prevalent in critically ill COVID-19 patients: Are they risk factors for disease severity?</b>]]> http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742020001000008&lng=en&nrm=iso&tlng=en Fungal co-infections, especially with Aspergillus and Candida species, are prevalent in hospitalised COVID-19 patients, and could influence patient outcomes and hamper treatment efforts. However, information about and elucidation of the causal relationship between fungal co-infections and COVID-19 disease outcomes or severity in patients are still lacking. Such information, if and when available, will help facilitate appropriate case management. <![CDATA[<b>Implementing malaria control in South Africa, Eswatini and southern Mozambique during the COVID-19 pandemic</b>]]> http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742020001000009&lng=en&nrm=iso&tlng=en The COVID-19 pandemic has strained healthcare delivery systems in a number of southern African countries. Despite this, it is imperative that malaria control and elimination activities continue, especially to reduce as far as possible the number and rate of hospitalisations caused by malaria. The implementation of enhanced malaria control/elimination activities in the context of COVID-19 requires measures to protect healthcare workers and the communities they serve. The aim of this review is therefore to present innovative ideas for the timely implementation of malaria control without increasing the risk of COVID-19 to healthcare workers and communities. Specific recommendations for parasite and vector surveillance, diagnosis, case management, mosquito vector control and community outreach and sensitisation are given. <![CDATA[<b>Prolonged treatment of COVID-19 pneumonia with high-flow nasal oxygen: A story of oxygen and resilience</b>]]> http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742020001000010&lng=en&nrm=iso&tlng=en The COVID-19 pandemic has placed significant strain on the oxygen delivery infrastructure of health facilities in resource-constrained health systems. In this case report, we describe a patient with severe COVID-19 pneumonia who was managed with high-flow nasal oxygen for 40 days, with an eventual successful outcome. We discuss the oxygen delivery infrastructure needed to offer this intervention, as well as the psychosocial impact on those undergoing treatment. <![CDATA[<b>COVID deaths in South Africa: 99 days since South Africa's first death</b>]]> http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742020001000011&lng=en&nrm=iso&tlng=en BACKGROUND. Understanding the pattern of deaths from COVID-19 in South Africa (SA) is critical to identifying individuals at high risk of dying from the disease. The Minister of Health set up a daily reporting mechanism to obtain timeous details of COVID-19 deaths from the provinces to track mortality patterns.OBJECTIVES. To provide an epidemiological analysis of the first COVID-19 deaths in SA.METHODS. Provincial deaths data from 28 March to 3 July 2020 were cleaned, information on comorbidities was standardised, and data were aggregated into a single data set. Analysis was performed by age, sex, province, date of death and comorbidities.RESULTS. SA reported 3 088 deaths from COVID-19, i.e. an age-standardised death rate of 64.5 (95% confidence interval (CI) 62.3 - 66.8) deaths per million population. Most deaths occurred in Western Cape (65.5%) followed by Eastern Cape (16.8%) and Gauteng (11.3%). The median age of death was 61 years (interquartile range 52 - 71). Males had a 1.5 times higher death rate compared with females. Individuals with two or more comorbidities accounted for 58.6% (95% CI 56.6 - 60.5) of deaths. Hypertension and diabetes were the most common comorbidities reported, and HIV and tuberculosis were more common in individuals aged <50 years.CONCLUSIONS. Data collection for COVID-19 deaths in provinces must be standardised. Even though the data had limitations, these findings can be used by the SA government to manage the pandemic and identify individuals who are at high risk of dying from COVID-19. <![CDATA[<b>A descriptive analysis of the effect of the national COVID-19 lockdown on the workload and case mix of patients presenting to a district-level emergency centre in Cape Town, South Africa</b>]]> http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742020001000012&lng=en&nrm=iso&tlng=en BACKGROUND. The global COVID-19 pandemic caused many countries to institute nationwide lockdowns to limit the spread of the disease.OBJECTIVES. To describe the effect of the national COVID-19 lockdown in South Africa (SA) on the workload and case mix of patients presenting to a district-level emergency centre.METHODS. The electronic patient tracking and registration database at Mitchells Plain Hospital, a district-level hospital in Cape Town, was retrospectively analysed. The 5-week lockdown period (27 March - 30 April 2020) was compared with a similar period immediately before the lockdown (21 February - 26 March). A comparison was also made with corresponding time periods during 2018 and 2019. Patient demographics, characteristics, diagnoses and disposition, as well as process times, were compared.RESULTS. A total of 26 164 emergency centre visits were analysed (8 297 in 2020, 9 726 in 2019, 8 141 in 2018). There was a reduction of 15% in overall emergency centre visits from 2019 to 2020 (non-trauma 14%, trauma 20%). A 35% decrease was seen between the 2020 lockdown period and the 5-week period before lockdown (non-trauma 33%, trauma 43%), and the reduced number of visits stayed similar throughout the lockdown period. The median age increased by 5 years during the 2020 lockdown period, along with an 8% decrease in patients aged <12 years. High-acuity patients increased by 6% and the emergency centre mortality rate increased by 1%. All process times were shorter during the lockdown period (time to triage -24%, time to consultation -56%, time to disposition decision -29%, time in the emergency centre -20%).CONCLUSIONS. The SA national COVID-19 lockdown resulted in a substantial decrease in the number of patients presenting to the emergency centre. It is yet to be seen how quickly emergency centre volumes will recover as lockdown measures are eased. <![CDATA[<b>A rapid review of the effectiveness of screening practices at airports, land borders and ports to reduce the transmission of respiratory infectious diseases such as COVID-19</b>]]> http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742020001000013&lng=en&nrm=iso&tlng=en BACKGROUND. Travel screening for infectious diseases is often implemented to delay or prevent the entry of infected persons to a country/area.OBJECTIVES. To evaluate the effectiveness of different point-of-entry screening strategies in achieving a reduction in imported COVID-19 transmission.METHODS. A rapid evidence review was conducted, systematically searching PubMed and Google Scholar and grey literature on 27 March 2020.RESULTS. We screened 1 194 records. Nine potential full-text articles were assessed for eligibility and included. Three articles investigated the effectiveness of entry-based thermal and body temperature scanning. Entry-based infrared thermal or body temperature scanning for COVID-19 was unlikely to be effective. Two systematic reviews found no additional benefit of travel restrictions/screening. In a COVID-19 modelling study, airport screening was not effective, with exit and entry thermal scanning identifying half and missing almost half of infected travellers. Two other modelling studies found that entry-based travel screening would achieve only modest delays in community transmission, while international travel quarantine could reduce case importations by 80%.CONCLUSIONS. There is insufficient evidence to support entry and exit screening at points of entry, as these strategies detect just over half of the infected cases, missing almost half at entry points. The benefits of airport screening therefore need to be context specific and weighed against the resources and cost of implementation, the contribution of imported cases to total cases, and the benefits of identifying 50% of cases in the South African context with the country's high HIV and tuberculosis prevalence and limited resources to deal with a pandemic of this nature.